Biochemicals & Reagents - I To Z Listing

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Phenytoin sodium is a medication used to treat seizures in epilepsy. It works by stabilizing neuronal membranes to control seizure activity. Phenytoin sodium can be given orally or intravenously and has nonlinear pharmacokinetics, meaning dosage changes can significantly alter drug levels. Target-controlled infusion (TCI) is a method using computerized systems to control drug infusion rates to achieve a specific drug concentration in the bloodstream. TCI uses mathematical models based on patient characteristics to determine the appropriate dose. While mainly used in anesthesia, TCI is being explored for other medications. Potential application of TCI with phenytoin

• Precision and Consistency: TCI may help maintain consistent drug levels, potentially improving seizure control and reducing side effects.
• Rapid Adjustment: TCI systems can quickly adjust dosages, which may be helpful in managing acute seizures.
• Safety: By keeping drug concentrations within the therapeutic range, TCI might help minimize adverse reactions associated with phenytoin. 

Limitations

• Pharmacokinetic Variability: TCI accuracy depends on precise models, which can be challenging due to individual patient variations.
• Monitoring Requirements: TCI requires continuous monitoring of the patient.
• Limited Availability for Phenytoin: While TCI is established for some drugs, more research and regulatory approval are needed for widespread use with phenytoin. 

In conclusion, combining phenytoin sodium with TCI shows potential for more precise, safe, and efficient antiepileptic treatment. However, more research is needed to address limitations and ensure optimal clinical use. This is for inform

Additional Information:

• Item Code: D1331
• Delivery Time: Ready Stock
• Packaging Details: Glass Bottle

Product Details:

Methanol Specially Dried for KF is a highly purified and dried form of methanol, specifically formulated for use in Karl Fischer (KF) titration, a method for determining water content in various substances. It is characterized by its extremely low water content, typically less than 0.02%, and high purity, often 99.5% or higher. This ensures accurate and reliable water content determination in analytical and laboratory settings. Key Characteristics:

• Low Water Content: The primary feature of Methanol Specially Dried for KF is its extremely low water content, which is crucial for accurate KF titrations. 
• High Purity: It is a highly purified form of methanol, ensuring that the solvent itself doesn't interfere with the water determination process. 
• Clear and Colorless: It is a clear, colorless liquid, as expected for pure methanol. 
• Characteristic Odor: It has the characteristic odor associated with methanol. 
• Specific Gravity: The specific gravity is typically around 0.790-0.792 g/mL at 20°C. 
• Solubility: Methanol is highly soluble in water and other organic solvents. 
• Grade: It is often available as AR (Analar) or LR (Laboratory Reagent) grade, indicating its suitability for analytical applications. 
• Packaging: It is typically packaged in glass bottles to minimize contamination. 

Applications:

• Karl Fischer Titration:It is the most commonly used medium in KF titrations due to its low water content and high purity. 
• Non-Aqueous Titrations:It can also be used in other non-aqueous titrations where a low water content solvent is needed. 
• Analytical Chemistry:It is used in various analytical procedures where accurate water determination is essential. 

Additional Information:

• Delivery Time: Ready Stock
• Packaging Details: Box